Journal: Cell reports

Article Title: Inactivation of medial entorhinal cortex selectively disrupts learning of interval timing

doi: 10.1016/j.celrep.2020.108163

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Bacterial and Virus Strains AAV8.hSyn.Jaws-KGC.GFP-ER2.WPRE.hGH Addgene 65014-AAV8 pAAV8-hSyn-EGFP Addgene 50465-AAV8 Chemicals, Peptides, and Recombinant Proteins NeuroTrace 530/615 Red Fluorescent Nissl Stain Invitrogen {"type":"entrez-nucleotide","attrs":{"text":"N21482","term_id":"1126652","term_text":"N21482"}} N21482 NeuroTrace 435/455 Blue Fluorescent Nissl Stain Invitrogen {"type":"entrez-nucleotide","attrs":{"text":"N21479","term_id":"1126649","term_text":"N21479"}} N21479 Experimental Models: Organisms/Strains Mouse: C57-BL6 Charles River N/A Software and Algorithms MATALB Mathworks https://www.mathworks.com/products/matlab.html ; P-Clamp Axon Instruments www.moleculardevices.com Open in a separate window KEY RESOURCES TABLE Mice learn interval timing task and report duration through immobile waiting Optogenetic inactivation of MEC disrupts learning of interval timing behavior Learning deficit revealed by MEC inactivation specifically during timing behavior MEC inactivation did not significantly impair timing behavior after learning

Techniques: Recombinant, Staining, Software